By Ian Lekus

The first I learned of PrEP, or pre-exposure prophylaxis, came from the signs and postcards around Fenway Health, Boston’s LGBT community health center. Those advertisements appeared as Fenway served as one of two U.S. research sites for PrEP, in advance of the U.S. Food and Drug Administration approving Truvada in July 2012 as the first drug deemed safe and effective for reducing the risk of HIV transmission.[1] As I started learning more, I quickly discovered how its advocates frequently compare PrEP to oral contraceptives. One PrEP researcher I consulted with early on in my investigations explicitly drew the parallel to her decision to use the Pill a few years earlier. Some of the similarities jump out immediately: for example, like oral contraceptives, PrEP — a pill taken daily to prevent HIV infection — separates prevention from the act of sexual intercourse itself.