By Lara Freidenfelds

What would you do if you desperately wanted to have a baby, and your spouse had HIV? In the mid-1990s, the introduction of highly-effective HIV drug regimens turned HIV from a death sentence into a chronic condition. People with HIV and their life partners could begin to imagine creating families and living to see their children grow up. But it was not until 2014 that researchers and policy-makers approved a prophylactic regimen that effectively protects against HIV-transmission even without condom use. (It still is not officially condoned for family-building purposes, but some physicians are willing to prescribe it for that purpose.) For almost two decades, HIV-discordant couples faced a special kind of infertility: it was childlessness caused by the threat of illness, by fear, and by a traumatized, cautious public health and medical community that could not move beyond its initial message, that “only condoms prevent HIV transmission.”

A new e-book, Positively Negative: Love, Pregnancy, and Science’s Surprising Victory over HIV, takes us into the lives of two couples who lived this history.